TNF Receptor-Associated Factor 4 (TRAF4) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: TNF Receptor-Associated Factor 4 (TRAF4)
Immunogen: TNF receptor-associated factor 4

Rabbit

Human, Mouse, Rat

Concentration: 2 mg/ml

WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Observed MW: 54 kDa

≥ 95% (SDS-PAGE)

Purified by immunogen affinity chromatography.

100 µg

Liquid

ELISA, WB, IHC, IF/ICC

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9BUZ4

TRAF-4,TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4,RING finger protein 83

Antibody anti-TRAF4

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

TRAF4 is a unique member of the TRAF family that regulates signaling pathways involved in cellular processes such as survival, migration, and cytoskeletal organization. Unlike other TRAF proteins, TRAF4 interacts with various receptors, including TNFR superfamily members, Toll-like receptors, and growth factor receptors, linking them to downstream signaling cascades like Akt, MAPK, and NF-κB. TRAF4 is highly expressed during embryonic development and in epithelial cells, where it plays a role in tissue morphogenesis, cell polarity, and immune responses. It also participates in reactive oxygen species (ROS) regulation and ciliary function. Dysregulation of TRAF4 has been associated with cancer progression, where it promotes epithelial-mesenchymal transition (EMT), cell migration, and invasion. Knockout studies reveal defects in neural tube closure, abnormal epithelial development, and impaired ciliary function, emphasizing its roles in developmental processes and cytoskeletal regulation.