TNF Receptor Associated Factor 4 (TRAF4) Antibody
221€ (50 µg)
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Name
TNF Receptor Associated Factor 4 (TRAF4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx327309
Tested Applications
ELISA, WB
Description
TRAF4 Antibody is a Rabbit Polyclonal against TRAF4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Associated Factor 4 (TRAF4) Immunogen: Synthesized peptide derived from the Internal region of human TRAF4. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BUZ4 |
| Gene ID | 9618 |
| Alias | TRAF-4,TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4,RING finger protein 83 |
| Background | Antibody anti-TRAF4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TRAF4 is a unique member of the TRAF family that regulates signaling pathways involved in cellular processes such as survival, migration, and cytoskeletal organization. Unlike other TRAF proteins, TRAF4 interacts with various receptors, including TNFR superfamily members, Toll-like receptors, and growth factor receptors, linking them to downstream signaling cascades like Akt, MAPK, and NF-κB. TRAF4 is highly expressed during embryonic development and in epithelial cells, where it plays a role in tissue morphogenesis, cell polarity, and immune responses. It also participates in reactive oxygen species (ROS) regulation and ciliary function. Dysregulation of TRAF4 has been associated with cancer progression, where it promotes epithelial-mesenchymal transition (EMT), cell migration, and invasion. Knockout studies reveal defects in neural tube closure, abnormal epithelial development, and impaired ciliary function, emphasizing its roles in developmental processes and cytoskeletal regulation.
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