TNF Receptor-Associated Factor 6 (TRAF6) Antibody
292.5€ (80 µl)
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Name
TNF Receptor-Associated Factor 6 (TRAF6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031071
Tested Applications
ELISA, WB
Description
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq].
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor-Associated Factor 6 (TRAF6) Immunogen: KLH-conjugated synthetic peptide between 314-343 amino acids from the Central region of human TRAF6. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 59.6 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y4K3 |
| Alias | TRAF-6,TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6 |
| Background | Antibody anti-TRAF6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TRAF6 is a multifunctional adaptor protein that regulates signaling downstream of TNFR superfamily members, Toll-like receptors (TLRs), and IL-1 receptors. It activates key pathways, including NF-κB, JNK, and Akt, to mediate inflammatory responses, innate immunity, and bone homeostasis. TRAF6 also functions as an E3 ubiquitin ligase, facilitating K63-linked ubiquitination of signaling intermediates like TAK1, IKK, and Akt to promote downstream activation. It plays essential roles in immune cell activation, osteoclast differentiation, and autophagy regulation. TRAF6 is widely expressed in immune cells, bone tissue, and epithelial cells, where it supports pathogen recognition, inflammatory signaling, and bone remodeling. Dysregulation of TRAF6 is associated with autoimmune diseases, chronic inflammation, osteoporosis, and cancer due to hyperactive NF-κB signaling and impaired bone resorption. Knockout models exhibit immune deficiencies, defective TLR signaling, impaired bone development, and increased susceptibility to infections, underscoring its critical role in immunity, inflammation, and skeletal homeostasis.
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