TNF Receptor-Associated Factor 7 (TRAF7) Antibody
377€ (100 µg)
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Name
TNF Receptor-Associated Factor 7 (TRAF7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx238922
Tested Applications
ELISA, WB, IHC, IP
Description
TRAF7 Antibody is a Rabbit Polyclonal against TRAF7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor-Associated Factor 7 (TRAF7) Immunogen: TNF receptor-associated factor 7 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 67-75 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6Q0C0 |
| Gene ID | 84231 |
| OMIM | 606692 |
| Alias | RFWD1,RNF119,CAFDADD,RING finger protein 119,RING-type E3 ubiquitin transferase TRAF7 |
| Background | Antibody anti-TRAF7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TRAF7 is a unique member of the TRAF family that functions as both a signaling adaptor protein and an E3 ubiquitin ligase. Unlike other TRAFs, TRAF7 primarily regulates noncanonical pathways, including MAPK, NF-κB, and apoptosis signaling, through its role in ubiquitination and protein degradation. TRAF7 interacts with TNF receptor family members, Toll-like receptors (TLRs), and transcription factors like p53 to regulate inflammation, cell survival, and apoptosis. It is widely expressed in epithelial tissues, immune cells, and the nervous system, where it plays roles in tissue homeostasis, cellular stress responses, and immune regulation. Dysregulation of TRAF7 has been associated with cancers, including meningiomas and sarcomas, where it affects cell proliferation and survival. Functional studies demonstrate its dual role in promoting cell survival and apoptosis, depending on cellular context, highlighting its significance in signaling regulation, ubiquitination, and tumor suppression.
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