Zinc Finger And BTB Domain-Containing Protein 7B (ZBTB7B) Antibody
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Description
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors.It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively.ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes.It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Zinc Finger And BTB Domain-Containing Protein 7B (ZBTB7B) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15156 |
| Gene ID | 51043 |
| OMIM | 607646 |
| Background | Antibody anti-ZBTB7B |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
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Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors(thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes(By similarity).
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