Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ZC3HAV1 Antibody is a Rabbit Polyclonal against ZC3HAV1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000 - 1/10000, IHC: 1/20 - 1/200, IP: 1/1000 - 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z2W4 |
| Gene ID | 56829 |
| OMIM | 607312 |
| Background | Antibody anti-ZC3HAV1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Related Products

ZC3HAV1 antibody
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).
Ver Producto
Recombinant Human ZC3HAV1
Ver Producto
Zinc Finger CCCH-Type Antiviral Protein 1 (ZC3HAV1) Antibody
ZC3HAV1 Antibody is a Rabbit Polyclonal Antibody against ZC3HAV1.
Ver Producto