Zinc Finger CCCH-Type With G Patch Domain-Containing Protein (ZGPAT) Antibody

Name: Zinc Finger CCCH-Type With G Patch Domain-Containing Protein (ZGPAT) Antibody
Brand: Abbexa
SKU: abx036750
Price: 357.5 EUR
Availability: OnlineOnly

357.5€ (100 µg)

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Zinc Finger CCCH-Type With G Patch Domain-Containing Protein (ZGPAT) Antibody

Description

Rabbit Polyclonal against the ZGPAT protein.

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Product specifications

Category	Primary Antibodies
Immunogen Target	Zinc Finger CCCH-Type With G Patch Domain-Containing Protein (ZGPAT)
Host	Rabbit
Reactivity	Human
Recommended Dilution	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality	Polyclonal
Conjugation	Unconjugated
Isotype	IgG
Purification	Purified by antigen affinity column chromatography.
Size 1	100 µg
Size 2	1 mg
Form	Lyophilized
Tested Applications	ELISA, WB, IHC
Buffer	Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability	Shipped within 7-15 working days.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice	No
Background	Antibody anti-ZGPAT
Status	RUO
Note	Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -

Descripción

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ZGPAT antibody

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.

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