Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
195€ (20 µl)
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Name
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000674
Tested Applications
ELISA, WB
Description
CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Caspase Recruitment Domain Family Member 8 (CARD8) Immunogen: Synthetic peptide corresponding to CARD8. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 61 kDa Observed MW: 60 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2G2 |
| Gene ID | 22900 |
| NCBI Accession | NP_003796.1 |
| Alias | CARDINAL,DACAR,DAKAR,NDPP,NDPP1,TUCAN,CARD-inhibitor of NF-kappa-B-activating ligand |
| Background | Antibody anti-CARD8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARD8 is another member of the CARD protein family, involved in immune response regulation, particularly in the activation of inflammatory pathways. It contains a caspase recruitment domain (CARD), which is crucial for its role in signal transduction. CARD8 is involved in the regulation of the inflammasome, a complex that mediates the activation of caspase-1, leading to the production of pro-inflammatory cytokines such as IL-1β and IL-18. This protein is particularly important for detecting pathogens and cellular damage, promoting an appropriate inflammatory response. However, CARD8 can also regulate immune responses to prevent excessive inflammation, which is implicated in various chronic inflammatory diseases and autoimmune conditions. Research into CARD8 focuses on its role in diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis, where abnormal inflammasome activation is observed.
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