Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
637€ (100 µl)
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Name
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx111430
Tested Applications
ELISA, IHC, IF/ICC
Description
Caspase Recruitment Domain Family, Member 8 Antibody is a Rabbit Polyclonal antibody against Caspase Recruitment Domain Family, Member 8.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Caspase Recruitment Domain Family Member 8 (CARD8) Immunogen: Human CARD8. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2G2 |
| Gene ID | 22900 |
| NCBI Accession | XM_006723104.3 |
| OMIM | 609051 |
| Alias | CARDINAL,DACAR,DAKAR,NDPP,NDPP1,TUCAN,CARD-inhibitor of NF-kappa-B-activating ligand |
| Background | Antibody anti-CARD8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARD8 is another member of the CARD protein family, involved in immune response regulation, particularly in the activation of inflammatory pathways. It contains a caspase recruitment domain (CARD), which is crucial for its role in signal transduction. CARD8 is involved in the regulation of the inflammasome, a complex that mediates the activation of caspase-1, leading to the production of pro-inflammatory cytokines such as IL-1β and IL-18. This protein is particularly important for detecting pathogens and cellular damage, promoting an appropriate inflammatory response. However, CARD8 can also regulate immune responses to prevent excessive inflammation, which is implicated in various chronic inflammatory diseases and autoimmune conditions. Research into CARD8 focuses on its role in diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis, where abnormal inflammasome activation is observed.
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