Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein

Este producto es parte de SIT1 - Signaling threshold-regulating transmembrane adapter 1
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234€ (10 µg)

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935106861
info@markelab.com
name
Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069095
tested applications
WB, SDS-PAGE

Description

Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) is a recombinant Rat protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ser2-Pro175
Tag: N-terminal His tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 22.8 kDa
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q5M869
Alias
SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1
Background
Protein SIT1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.

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