Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029063
tested applications
ELISA, WB
Description
Negatively regulates TCR (T-cell antigen receptor) mediated signaling in T-cells. Involved in positive selection of T-cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y3P8 |
| Alias | SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1 |
| Background | Antibody anti-SIT1 |
| Status | RUO |
Descripción
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.
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