Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody
273€ (200 µl)
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935106861
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name
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433276
tested applications
P-ELISA
Description
SIT1 Antibody is a Goat Polyclonal antibody against SIT1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 27240 |
| NCBI Accession | NP_055265.1 |
| Alias | SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1 |
| Background | Antibody anti-SIT1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.
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